使用简短计算机化认知筛查测试检测个体内部认知下降(PDF) Intraindividual cognitive decline using a brief computerized cognitive screening test

环球医讯 / 认知障碍来源：www.academia.edu美国 - 英语2026-07-27 21:52:58 - 阅读时长22分钟 - 10871字
本研究通过为期12个月的纵向观察，评估了263名50岁以上健康社区居住成年人的认知表现变化趋势。研究采用简短的计算机化认知测试（CogState）在基线及3、6、9、12个月随访时进行评估，利用线性混合模型分析认知测量指标的年龄调整变化斜率。研究发现，通过定义情景记忆测量的年龄调整平均斜率和95%置信区间，可以识别出认知下降超出预期的个体，其中部分人虽未达到轻度认知障碍标准，但已显示出阿尔茨海默病的早期生物标志物特征，表明个体内部认知下降可能是检测早期阿尔茨海默病病理的潜在指标，为早期诊断提供了新思路。
健康社区老年人认知下降计算机化认知筛查测试早期阿尔茨海默病检测情景记忆测量淀粉样蛋白PET
使用简短计算机化认知筛查测试检测个体内部认知下降

摘要

背景：记忆和认知的进行性个体内部下降是痴呆的特征，可能有助于检测非常早期的阿尔茨海默病病理。

方法：本研究评估了263名50岁以上健康社区居住成年志愿者在12个月期间的认知表现斜率。参与者在基线以及3、6、9和12个月随访评估时完成了一套简短的计算机化认知测试（CogState）。使用线性混合模型来估计每个认知测量指标的年龄调整平均斜率和95%变化的置信区间。

结果：通过定义情景记忆测量的年龄调整平均斜率和95%置信区间，识别出认知下降大于预期（等于或低于下降的第五百分位水平）的个体。从这些个体中，四名完成了全面的医学、神经学和神经心理学评估，他们均不符合轻度认知障碍的标准，但有三名（75%）具有阳性的淀粉样蛋白-正电子发射断层扫描结果。

结论：在其他方面健康的社区居住老年人中可以检测到认知表现的个体内部下降，这可能值得进一步研究作为早期阿尔茨海默病病理的潜在指标。

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