呼出气体挥发性有机化合物组作为肠道菌群驱动健康与疾病的无创反映Breath volatilome as a non-invasive reflection of gut microbiota-driven health and disease: Cell Metabolism

环球医讯 / 健康研究来源:www.cell.com比利时 - 英语2026-08-19 22:06:14 - 阅读时长4分钟 - 1907字
本研究通过在无菌小鼠中整合多组学分析并开发呼出气体收集平台,为呼出气体挥发性有机化合物组作为无创手段预测儿童哮喘相关菌种丰度提供了机制性证据。该研究表明肠道微生物组与呼出气体成分之间存在密切关联,为开发基于呼吸分析的非侵入性诊断方法开辟了新途径,有望用于监测肠道菌群变化及其对健康的影响,特别是在儿科呼吸系统疾病的早期预测和干预方面具有潜在应用价值,展示了微生物-宿主相互作用研究的创新方法。
健康疾病呼出气体挥发性有机化合物组肠道菌群无创检测生物标志物哮喘儿童梭杆菌属多组学分析
呼出气体挥发性有机化合物组作为肠道菌群驱动健康与疾病的无创反映

摘要

通过在无菌小鼠中整合多组学分析并开发呼出气体收集平台,Hernandez-Leyva等人¹提供了机制性证据,表明呼出气体挥发性有机化合物组可用作无创手段,预测儿童中与哮喘相关的梭杆菌属菌种(Eubacterium siraeum)的丰度。

参考文献

  1. Hernandez-Leyva, A.J. ∙ Berna, A.Z. ∙ Bui, M.H. ... The gut microbiota shapes the human and murine breath volatilome. Cell Metab. 2026; 38:779-793.e8
  2. (1931). 希波克拉底. Translated by W.H.S. Jones. 剑桥, 马萨诸塞州: (哈佛大学出版社).
  3. Pauling, L. ∙ Robinson, A.B. ∙ Teranishi, R. ... Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography. Proc. Natl. Acad. Sci. USA. 1971; 68:2374-2376
  4. Gustafsson, L.E. ∙ Leone, A.M. ∙ Persson, M.G. ... Endogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans. Biochem. Biophys. Res. Commun. 1991; 181:852-857
  5. Phillips, M. ∙ Gleeson, K. ∙ Hughes, J.M. ... Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet. 1999; 353:1930-1933
  6. Özçam, M. ∙ Lynch, S.V. The gut-airway microbiome axis in health and respiratory diseases. Nat. Rev. Microbiol. 2024; 22:492-506
  7. Smolinska, A. ∙ Tedjo, D.I. ∙ Blanchet, L. ... Volatile metabolites in breath strongly correlate with gut microbiome in CD patients. Anal. Chim. Acta. 2018; 1025:1-11
  8. Neyrinck, A.M. ∙ Rodriguez, J. ∙ Zhang, Z. ... Noninvasive monitoring of fibre fermentation in healthy volunteers by analyzing breath volatile metabolites: lessons from the FiberTAG intervention study. Gut Microbes. 2021; 13:1-16
  9. Neyrinck, A.M. ∙ Rodriguez, J. ∙ Zhang, Z. ... Breath volatile metabolome reveals the impact of dietary fibres on the gut microbiota: Proof of concept in healthy volunteers. EBioMedicine. 2022; 80, 104051
  10. Hageman, J.H.J. ∙ Nieuwenhuizen, A.G. ∙ van Ruth, S.M. ... Application of Volatile Organic Compound Analysis in a Nutritional Intervention Study: Differential Responses during Five Hours Following Consumption of a High- and a Low-Fat Dairy Drink. Mol. Nutr. Food Res. 2019; 63, e1900189

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